Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody

The efficacy of engaging multiple drug targets using bispecific antibodies (BsAbs) is affected by the relative cell-surface protein levels of the respective targets. In this work, the receptor density values were correlated to the in vitro activity of a BsAb (JNJ-61186372) targeting epidermal growth...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jarantow, Stephen W., Bushey, Barbara S., Pardinas, Jose R., Boakye, Ken, Lacy, Eilyn R., Sanders, Renouard, Sepulveda, Manuel A., Moores, Sheri L., Chiu, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598982/
https://ncbi.nlm.nih.gov/pubmed/26260789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.651653
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