EXTH-43. DIFFERENTIATED PHARMACOLOGY OF THE IMIPRIDONE ONC201, THE FIRST SELECTIVE DRD2/3 ANTAGONIST IN CLINICAL NEURO-ONCOLOGY

door Madhukar, Neel, Prabhu, Varun Vijay, Anantharaman, Lakshmi, Sulli, Chidananda, Davidson, Edgar, Deacon, Sean, Tarapore, Rohinton, Rucker, Joseph, Charter, Neil, Doranz, Benjamin, Oster, Wolfgang, Elemento, Olivier, Free, R Benjamin, Sibley, David, Allen, Joshua E
Gepubliceerd in Neuro Oncol (2017)

DDIS-12. ONC201: THE FIRST SELECTIVE, NON-COMPETITIVE DRD2/3 ANTAGONIST FOR CLINICAL NEURO-ONCOLOGY

door Vijay Prabhu, Varun, Madhukar, Neel, Anantharaman, Lakshmi, Sulli, Chidananda, Davidson, Edgar, Deacon, Sean, Tarapore, Rohinton, Rucker, Joseph, Charter, Neil, Doranz, Benjamin, Oster, Wolfgang, Stogniew, Martin, Elemento, Olivier, Free, R Benjamin, Sibley, David, Allen, Joshua
Gepubliceerd in Neuro Oncol (2018)

DDIS-20. IMIPRIDONE STRUCTURE ACTIVITY RELATIONSHIP UNCOVERS ONC206 AS THE NEXT BITOPIC DRD2 ANTAGONIST FOR ONCOLOGY WITH DIFFERENTIATED RECEPTOR PHARMACOLOGY

door Prabhu, Varun, Cuoco, Caroline, Jung, Jinkyu, Rahman Kawakibi, Abed, Willette, Blair, Day, Marilyn, Anantharaman, Lakshmi, Charter, Neil, Rucker, Joseph, Doranz, Benjamin, Oster, Wolfgang, Stogniew, Martin, Gilbert, Mark, Benjamin Free, R, Sibley, David, Allen, Joshua
Gepubliceerd in Neuro Oncol (2019)

DDRE-33. MOLECULAR DIFFERENTIATION OF IMIPRIDONES ONC201 AND ONC206

door Prabhu, Varun, Cuoco, Caroline, Jung, Jinkyu, Morrow, Sara, Kawakibi, Abed Rahman, Willette, Blair, Day, Marilyn, Anantharaman, Lakshmi, Charter, Neil, Rucker, Joseph, Doranz, Benjamin, Basken, Joel, Stogniew, Martin, Gilbert, Mark, Free, R, Sibley, David, Allen, Joshua
Gepubliceerd in Neuro Oncol (2020)

EXTH-33. RECEPTOR PHARMACOLOGY OF ONC201: THE FIRST BITOPIC DRD2 ANTAGONIST FOR CLINICAL NEURO-ONCOLOGY

door Benjamin Free, R, Cuoco, Caroline, Prabhu, Varun, Willette, Blair, Day, Marilyn, Anantharaman, Lakshmi, Sulli, Chidananda, Davidson, Edgar, Deacon, Sean, Rucker, Joseph, Charter, Neil, Doranz, Benjamin, Oster, Wolfgang, Stogniew, Martin, Robert Lane, J, Sibley, David, Allen, Joshua
Gepubliceerd in Neuro Oncol (2019)

MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo‐allergic and anaphylactoid reactions

door Grimes, Jak, Desai, Sapna, Charter, Neil W., Lodge, James, Moita Santos, Rita, Isidro‐Llobet, Albert, Mason, Andrew M., Wu, Zining, Wolfe, Lawrence A., Anantharaman, Lakshmi, Green, Andrew, Bridges, Angela M., Dalmas Wilk, Deidre A., Brown, Andrew J.
Gepubliceerd in Pharmacol Res Perspect (2019)

Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia

door Nii, Takenobu, Prabhu, Varun V., Ruvolo, Vivian, Madhukar, Neel, Zhao, Ran, Mu, Hong, Heese, Lauren, Nishida, Yuki, Kojima, Kensuke, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Charter, Neil, Deacon, Sean, Elemento, Olivier, Allen, Joshua E., Oster, Wolfgang, Stogniew, Martin, Ishizawa, Jo, Andreeff, Michael
Gepubliceerd in Leukemia (2019)

EXTH-17. SELECTIVE, NON-COMPETITIVE DRD2/3 ANTAGONISM BY IMIPRIDONE ONC206 IS EFFECTIVE IN TUMORS WITH DOPAMINE RECEPTOR DYSREGULATION

door Prabhu, Varun Vijay, Madhukar, Neel, Tarapore, Rohinton, Garnett, Mathew, McDermott, Ultan, Benes, Cyril, Anantharaman, Lakshmi, Charter, Neil, Deacon, Sean, VanEngelenburg, Alexander, Rucker, Joseph, Doranz, Benjamin, Rusert, Jessica, Wechsler-Reya, Robert, Elemento, Olivier, Stogniew, Martin, Oster, Wolfgang, DeMorrow, Sharon, Free, R Benjamin, Sibley, David, Allen, Joshua
Gepubliceerd in Neuro Oncol (2018)

Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism

door Prabhu, Varun V., Madhukar, Neel S., Gilvary, Coryandar, Kline, C. Leah B., Oster, Sophie, El-Deiry, Wafik S., Elemento, Olivier, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Tarapore, Rohinton S., Deacon, Sean, Charter, Neil, Jung, Jinkyu, Park, Deric M., Gilbert, Mark R., Rusert, Jessica, Wechsler-Reya, Robert, Arrillaga-Romany, Isabel, Batchelor, Tracy T., Wen, Patrick Y., Oster, Wolfgang, Allen, Joshua E.
Gepubliceerd in Clin Cancer Res (2018)