MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo‐allergic and anaphylactoid reactions

Activation of MrgX2, an orphan G protein‐coupled receptor expressed on mast cells, leads to degranulation and histamine release. Human MrgX2 binds promiscuously to structurally diverse peptides and small molecules that tend to have basic properties (basic secretagogues), resulting in acute histamine...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Grimes, Jak, Desai, Sapna, Charter, Neil W., Lodge, James, Moita Santos, Rita, Isidro‐Llobet, Albert, Mason, Andrew M., Wu, Zining, Wolfe, Lawrence A., Anantharaman, Lakshmi, Green, Andrew, Bridges, Angela M., Dalmas Wilk, Deidre A., Brown, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887720/
https://ncbi.nlm.nih.gov/pubmed/31832205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.547
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