Cleaning up the environment in juvenile myelomonocytic leukemia

par Deng, Lisa, Chan, Rebecca J.
Publié dans Transl Cancer Res (2017)

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

par Chan, Rebecca J., Feng, Gen-Sheng
Publié 2007

Shp2 function in hematopoietic stem cell biology and leukemogenesis

par Nabinger, Sarah C., Chan, Rebecca J.
Publié dans Curr Opin Hematol (2012)

Activating PTPN11 Mutants Promote Hematopoietic Progenitor Cell Cycle Progression and Survival

par Yang, Zhenyun, Li, Yiping, Yin, Fuqin, Chan, Rebecca J.
Publié 2008

Pharmacologic inhibition of PI3K p110δ in mutant Shp2E76K-expressing mice

par Deng, Lisa, Virts, Elizabeth L., Kapur, Reuben, Chan, Rebecca J.
Publié dans Oncotarget (2017)

Novel Method of Murine Embryonic Stem Cell-Derived Osteoclast Development

par Goodman, Michael L., Chen, Shi, Yang, Feng-Chun, Chan, Rebecca J.
Publié 2009

Mice expressing Kras(G12D) in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia

par Tarnawsky, Stefan P., Kobayashi, Michihiro, Chan, Rebecca J., Yoder, Mervin C.
Publié dans J Clin Invest (2017)

Genetic and pharmacologic evidence implicating the p85α, but not p85β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloi...

par Munugalavadla, Veerendra, Sims, Emily C., Borneo, Jovencio, Chan, Rebecca J., Kapur, Reuben
Publié 2007

Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF

par Goodwin, Charles B., Yang, Zhenyun, Yin, Fuqin, Yu, Menggang, Chan, Rebecca J.
Publié 2012

Juvenile Myelomonocytic Leukemia: A Report from the 2(nd) International JMML Symposium

par Chan, Rebecca J., Cooper, Todd, Kratz, Christian P., Weiss, Brian, Loh, Mignon L.
Publié 2008

Yolk Sac Erythromyeloid Progenitors Expressing Gain Of Function PTPN11 Have Functional Features Of JMML But Are Not Sufficient To Cause Disease In Mice

par Tarnawsky, Stefan P., Yoshimoto, Momoko, Deng, Lisa, Chan, Rebecca J., Yoder, Mervin C.
Publié dans Dev Dyn (2017)

Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice

par Tarnawsky, Stefan P., Yu, Wen-Mei, Qu, Cheng-Kui, Chan, Rebecca J., Yoder, Mervin C.
Publié dans Oncotarget (2018)

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

par Chan, Rebecca J., Leedy, Melissa B., Munugalavadla, Veerendra, Voorhorst, Cara S., Li, Yanjun, Yu, Menggang, Kapur, Reuben
Publié 2005

Rapid development of myeloproliferative neoplasm in mice with Ptpn11(D61Y) mutation and haploinsufficient for Dnmt3a

par Deng, Lisa, Richine, Briana M., Virts, Elizabeth L., Jideonwo-Auman, Victoria N., Chan, Rebecca J., Kapur, Reuben
Publié dans Oncotarget (2017)

Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells

par Kondo, Takako, Sheets, Patrick L., Zopf, David A., Aloor, Heather L., Cummins, Theodore R., Chan, Rebecca J., Hashino, Eri
Publié 2008

Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors express...

par Yang, Zhenyun, Chen, Mia, Sitarski, Sarah A, Saadatzadeh, Tirajeh, Yin, Fuqin, Yu, Menggang, Yang, Feng-Chun, Chan, Rebecca J
Publié 2011

Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3

par Kondo, Takako, Matsuoka, Akihiro J., Shimomura, Atsushi, Koehler, Karl R., Chan, Rebecca J., Miller, Josef M., Srour, Edward F., Hashino, Eri
Publié 2011

Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

par Liu, Wei, Yu, Wen-Mei, Zhang, Jing, Chan, Rebecca J., Loh, Mignon L., Zhang, Zheng, Bunting, Kevin D., Qu, Cheng-Kui
Publié dans Leukemia (2016)

Kinase Suppressor of Ras (KSR1) modulates multiple Kit-ligand-dependent mast cell functions

par Chen, Mia, Burgin, Sarah, Staser, Karl, He, Yongzheng, Li, Xiaohong, Robinson, Mikella, Jiang, Li, Chan, Rebecca J., Ingram, David, Clapp, D. Wade
Publié 2011

p53 Is Renoprotective after Ischemic Kidney Injury by Reducing Inflammation

par Sutton, Timothy A., Hato, Takashi, Mai, Erik, Yoshimoto, Momoko, Kuehl, Sarah, Anderson, Melissa, Mang, Henry, Plotkin, Zoya, Chan, Rebecca J., Dagher, Pierre C.
Publié 2012