Cleaning up the environment in juvenile myelomonocytic leukemia

Por Deng, Lisa, Chan, Rebecca J.
Publicado no Transl Cancer Res (2017)

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

Por Chan, Rebecca J., Feng, Gen-Sheng
Publicado em 2007

Shp2 function in hematopoietic stem cell biology and leukemogenesis

Por Nabinger, Sarah C., Chan, Rebecca J.
Publicado no Curr Opin Hematol (2012)

Activating PTPN11 Mutants Promote Hematopoietic Progenitor Cell Cycle Progression and Survival

Por Yang, Zhenyun, Li, Yiping, Yin, Fuqin, Chan, Rebecca J.
Publicado em 2008

Pharmacologic inhibition of PI3K p110δ in mutant Shp2E76K-expressing mice

Por Deng, Lisa, Virts, Elizabeth L., Kapur, Reuben, Chan, Rebecca J.
Publicado no Oncotarget (2017)

Novel Method of Murine Embryonic Stem Cell-Derived Osteoclast Development

Por Goodman, Michael L., Chen, Shi, Yang, Feng-Chun, Chan, Rebecca J.
Publicado em 2009

Mice expressing Kras(G12D) in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia

Por Tarnawsky, Stefan P., Kobayashi, Michihiro, Chan, Rebecca J., Yoder, Mervin C.
Publicado no J Clin Invest (2017)

Genetic and pharmacologic evidence implicating the p85α, but not p85β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloi...

Por Munugalavadla, Veerendra, Sims, Emily C., Borneo, Jovencio, Chan, Rebecca J., Kapur, Reuben
Publicado em 2007

Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF

Por Goodwin, Charles B., Yang, Zhenyun, Yin, Fuqin, Yu, Menggang, Chan, Rebecca J.
Publicado em 2012

Juvenile Myelomonocytic Leukemia: A Report from the 2(nd) International JMML Symposium

Por Chan, Rebecca J., Cooper, Todd, Kratz, Christian P., Weiss, Brian, Loh, Mignon L.
Publicado em 2008

Yolk Sac Erythromyeloid Progenitors Expressing Gain Of Function PTPN11 Have Functional Features Of JMML But Are Not Sufficient To Cause Disease In Mice

Por Tarnawsky, Stefan P., Yoshimoto, Momoko, Deng, Lisa, Chan, Rebecca J., Yoder, Mervin C.
Publicado no Dev Dyn (2017)

Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice

Por Tarnawsky, Stefan P., Yu, Wen-Mei, Qu, Cheng-Kui, Chan, Rebecca J., Yoder, Mervin C.
Publicado no Oncotarget (2018)

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

Por Chan, Rebecca J., Leedy, Melissa B., Munugalavadla, Veerendra, Voorhorst, Cara S., Li, Yanjun, Yu, Menggang, Kapur, Reuben
Publicado em 2005

Rapid development of myeloproliferative neoplasm in mice with Ptpn11(D61Y) mutation and haploinsufficient for Dnmt3a

Por Deng, Lisa, Richine, Briana M., Virts, Elizabeth L., Jideonwo-Auman, Victoria N., Chan, Rebecca J., Kapur, Reuben
Publicado no Oncotarget (2017)

Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells

Por Kondo, Takako, Sheets, Patrick L., Zopf, David A., Aloor, Heather L., Cummins, Theodore R., Chan, Rebecca J., Hashino, Eri
Publicado em 2008

Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors express...

Por Yang, Zhenyun, Chen, Mia, Sitarski, Sarah A, Saadatzadeh, Tirajeh, Yin, Fuqin, Yu, Menggang, Yang, Feng-Chun, Chan, Rebecca J
Publicado em 2011

Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3

Por Kondo, Takako, Matsuoka, Akihiro J., Shimomura, Atsushi, Koehler, Karl R., Chan, Rebecca J., Miller, Josef M., Srour, Edward F., Hashino, Eri
Publicado em 2011

Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

Por Liu, Wei, Yu, Wen-Mei, Zhang, Jing, Chan, Rebecca J., Loh, Mignon L., Zhang, Zheng, Bunting, Kevin D., Qu, Cheng-Kui
Publicado no Leukemia (2016)

Kinase Suppressor of Ras (KSR1) modulates multiple Kit-ligand-dependent mast cell functions

Por Chen, Mia, Burgin, Sarah, Staser, Karl, He, Yongzheng, Li, Xiaohong, Robinson, Mikella, Jiang, Li, Chan, Rebecca J., Ingram, David, Clapp, D. Wade
Publicado em 2011

p53 Is Renoprotective after Ischemic Kidney Injury by Reducing Inflammation

Por Sutton, Timothy A., Hato, Takashi, Mai, Erik, Yoshimoto, Momoko, Kuehl, Sarah, Anderson, Melissa, Mang, Henry, Plotkin, Zoya, Chan, Rebecca J., Dagher, Pierre C.
Publicado em 2012