Yolk Sac Erythromyeloid Progenitors Expressing Gain Of Function PTPN11 Have Functional Features Of JMML But Are Not Sufficient To Cause Disease In Mice

BACKGROUND: Accumulating evidence suggests the origin of Juvenile Myelomonocytic Leukemia (JMML) is closely associated with fetal development. Nevertheless, the contribution of embryonic progenitors to JMML pathogenesis remains unexplored. We hypothesized that expression of JMML-initiating PTPN11 mu...

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發表在:Dev Dyn
Main Authors: Tarnawsky, Stefan P., Yoshimoto, Momoko, Deng, Lisa, Chan, Rebecca J., Yoder, Mervin C.
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828034/
https://ncbi.nlm.nih.gov/pubmed/28975680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.24598
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