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Yolk Sac Erythromyeloid Progenitors Expressing Gain Of Function PTPN11 Have Functional Features Of JMML But Are Not Sufficient To Cause Disease In Mice
BACKGROUND: Accumulating evidence suggests the origin of Juvenile Myelomonocytic Leukemia (JMML) is closely associated with fetal development. Nevertheless, the contribution of embryonic progenitors to JMML pathogenesis remains unexplored. We hypothesized that expression of JMML-initiating PTPN11 mu...
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| Publicado no: | Dev Dyn |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5828034/ https://ncbi.nlm.nih.gov/pubmed/28975680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.24598 |
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