Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF

Juvenile myelomonocytic leukemia is a lethal disease of children characterized by hypersensitivity of hematopoietic progenitors to granulocyte macrophage-colony stimulating factor. Mutations in PTPN11, the gene encoding the protein tyrosine phosphatase Shp2, are common in juvenile myelomonocytic leu...

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Autores principales: Goodwin, Charles B., Yang, Zhenyun, Yin, Fuqin, Yu, Menggang, Chan, Rebecca J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2012
Materias:
Original Articles and Brief Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396676/
https://ncbi.nlm.nih.gov/pubmed/22315502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.046896
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