PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Although hyperactivation of the Ras-Erk signaling pathway is known to underlie the pathogenesis of juvenile myelomonocytic leukemia (JMML), a fatal childhood disease, the PI3K-Akt signaling pathway is also dysregulated in this disease. Using genetic models, we demonstrate that inactivation of phosph...

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Detalhes bibliográficos
Main Authors: Goodwin, Charles B, Li, Xing Jun, Mali, Raghuveer S., Chan, Gordon, Kang, Michelle, Liu, Ziyue, Vanhaesebroeck, Bart, Neel, Benjamin G., Loh, Mignon L., Lannutti, Brian J., Kapur, Reuben, Chan, Rebecca J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007610/
https://ncbi.nlm.nih.gov/pubmed/24553178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-535104
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