Genetic and pharmacologic evidence implicating the p85α, but not p85β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis

Oncogenic activation loop KIT mutations are observed in acute myeloid leukemia (AML) and systemic mastocytosis (SM); however, unlike the KIT juxtamembrane mutants, the activation loop mutants are insensitive to imatinib mesylate. Furthermore, as prior studies primarily used heterologous cell lines,...

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Bibliografische gegevens
Hoofdauteurs: Munugalavadla, Veerendra, Sims, Emily C., Borneo, Jovencio, Chan, Rebecca J., Kapur, Reuben
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2007
Onderwerpen:
Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975845/
https://ncbi.nlm.nih.gov/pubmed/17483298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-053058
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