“Deadman” and “Passcode” microbial kill switches for bacterial containment

Por Chan, Clement T. Y., Lee, Jeong Wook, Cameron, D. Ewen, Bashor, Caleb J., Collins, James J.
Publicado no Nat Chem Biol (2015)

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

Por Chan, Clement T. Y., Dyavaiah, Madhu, DeMott, Michael S., Taghizadeh, Koli, Dedon, Peter C., Begley, Thomas J.
Publicado em 2010

Correction: A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

Por Chan, Clement T. Y., Dyavaiah, Madhu, DeMott, Michael S., Taghizadeh, Koli, Dedon, Peter C., Begley, Thomas J.
Publicado em 2011

Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset

Por Dimas, Rey P, Jiang, Xian-Li, Alberto de la Paz, Jose, Morcos, Faruck, Chan, Clement T Y
Publicado no Nucleic Acids Res (2019)

Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications

Por Patil, Ashish, Chan, Clement T.Y., Dyavaiah, Madhu, Rooney, John P., Dedon, Peter C., Begley, Thomas J.
Publicado em 2012

Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response

Por Patil, Ashish, Dyavaiah, Madhu, Joseph, Fraulin, Rooney, John P., Chan, Clement T.Y., Dedon, Peter C., Begley, Thomas J.
Publicado em 2012

Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes

Por Chan, Clement T. Y., Deng, Wenjun, Li, Fugen, DeMott, Michael S., Babu, I. Ramesh, Begley, Thomas J., Dedon, Peter C.
Publicado no Chem Res Toxicol (2015)

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

Por Chan, Clement T.Y., Pang, Yan Ling Joy, Deng, Wenjun, Babu, I. Ramesh, Dyavaiah, Madhu, Begley, Thomas J., Dedon, Peter C.
Publicado em 2012

Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy

Por Dimas, Rey P, Jordan, Benjamin R, Jiang, Xian-Li, Martini, Catherine, Glavy, Joseph S, Patterson, Dustin P, Morcos, Faruck, Chan, Clement T Y
Publicado no Nucleic Acids Res (2019)

Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

Por Fu, Dragony, Brophy, Jennifer A. N., Chan, Clement T. Y., Atmore, Kyle A., Begley, Ulrike, Paules, Richard S., Dedon, Peter C., Begley, Thomas J., Samson, Leona D.
Publicado em 2010

Identification of N(6),N(6)-Dimethyladenosine in Transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin

Por Chan, Clement T.Y., Chionh, Yok Hian, Ho, Chia-Hua, Lim, Kok Seong, Babu, I. Ramesh, Ang, Emily, Wenwei, Lin, Alonso, Sylvie, Dedon, Peter C.
Publicado no Molecules (2011)

Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs

Por Mandal, Debabrata, Köhrer, Caroline, Su, Dan, Babu, I. Ramesh, Chan, Clement T.Y., Liu, Yuchen, Söll, Dieter, Blum, Paul, Kuwahara, Masayasu, Dedon, Peter C., RajBhandary, Uttam L.
Publicado em 2014

Quantitative analysis of tRNA modifications by HPLC-coupled mass spectrometry

Por Su, Dan, Chan, Clement T.Y., Gu, Chen, Lim, Kok Seong, Chionh, Yok Hian, McBee, Megan E., Russell, Brandon S., Babu, I. Ramesh, Begley, Thomas J., Dedon, Peter C.
Publicado no Nat Protoc (2014)

Antibiotics induce redox-related physiological alterations as part of their lethality

Por Dwyer, Daniel J., Belenky, Peter A., Yang, Jason H., MacDonald, I. Cody, Martell, Jeffrey D., Takahashi, Noriko, Chan, Clement T. Y., Lobritz, Michael A., Braff, Dana, Schwarz, Eric G., Ye, Jonathan D., Pati, Mekhala, Vercruysse, Maarten, Ralifo, Paul S., Allison, Kyle R., Khalil, Ahmad S., Ting, Alice Y., Walker, Graham C., Collins, James J.
Publicado em 2014