Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response

S-phase and DNA damage promote increased ribonucleotide reductase (RNR) activity. Translation of RNR1 has been linked to the wobble uridine modifying enzyme tRNA methyltransferase 9 (Trm9). We predicted that changes in tRNA modification would translationally regulate RNR1 after DNA damage to promote...

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Autores principales: Patil, Ashish, Dyavaiah, Madhu, Joseph, Fraulin, Rooney, John P., Chan, Clement T.Y., Dedon, Peter C., Begley, Thomas J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478316/
https://ncbi.nlm.nih.gov/pubmed/22935709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21919
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