Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs

Most archaea and bacteria use a modified C in the anticodon wobble position of isoleucine tRNA to base pair with A but not with G of the mRNA. This allows the tRNA to read the isoleucine codon AUA without also reading the methionine codon AUG. To understand why a modified C, and not U or modified U,...

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Main Authors: Mandal, Debabrata, Köhrer, Caroline, Su, Dan, Babu, I. Ramesh, Chan, Clement T.Y., Liu, Yuchen, Söll, Dieter, Blum, Paul, Kuwahara, Masayasu, Dedon, Peter C., RajBhandary, Uttam L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895270/
https://ncbi.nlm.nih.gov/pubmed/24344322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.042358.113
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