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Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling

Previous work in yeast has suggested that modification of tRNAs, in particular uridine bases in the anticodon wobble position (U34), is linked to TOR (target of rapamycin) signaling. Hence, U34 modification mutants were found to be hypersensitive to TOR inhibition by rapamycin. To study whether this...

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Detalhes bibliográficos
Publicado no:Microb Cell
Main Authors: Scheidt, Viktor, Jüdes, André, Bär, Christian, Klassen, Roland, Schaffrath, Raffael
Formato: Artigo
Idioma:Inglês
Publicado em: Shared Science Publishers OG 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349137/
https://ncbi.nlm.nih.gov/pubmed/28357221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2014.12.179
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