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Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling

Previous work in yeast has suggested that modification of tRNAs, in particular uridine bases in the anticodon wobble position (U34), is linked to TOR (target of rapamycin) signaling. Hence, U34 modification mutants were found to be hypersensitive to TOR inhibition by rapamycin. To study whether this...

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Bibliografiske detaljer
Udgivet i:Microb Cell
Main Authors: Scheidt, Viktor, Jüdes, André, Bär, Christian, Klassen, Roland, Schaffrath, Raffael
Format: Artigo
Sprog:Inglês
Udgivet: Shared Science Publishers OG 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349137/
https://ncbi.nlm.nih.gov/pubmed/28357221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2014.12.179
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