Loss of Anticodon Wobble Uridine Modifications Affects tRNA(Lys) Function and Protein Levels in Saccharomyces cerevisiae

In eukaryotes, wobble uridines in the anticodons of tRNA(Lys) (UUU), tRNA(Glu) (UUC) and tRNA(Gln) (UUG) are modified to 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm(5)s(2)U). While mutations in subunits of the Elongator complex (Elp1-Elp6), which disable mcm(5) side chain formation, or removal of...

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Udgivet i:PLoS One
Main Authors: Klassen, Roland, Grunewald, Pia, Thüring, Kathrin L., Eichler, Christian, Helm, Mark, Schaffrath, Raffael
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352028/
https://ncbi.nlm.nih.gov/pubmed/25747122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119261
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