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Loss of Anticodon Wobble Uridine Modifications Affects tRNA(Lys) Function and Protein Levels in Saccharomyces cerevisiae
In eukaryotes, wobble uridines in the anticodons of tRNA(Lys) (UUU), tRNA(Glu) (UUC) and tRNA(Gln) (UUG) are modified to 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm(5)s(2)U). While mutations in subunits of the Elongator complex (Elp1-Elp6), which disable mcm(5) side chain formation, or removal of...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4352028/ https://ncbi.nlm.nih.gov/pubmed/25747122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119261 |
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