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“Deadman” and “Passcode” microbial kill switches for bacterial containment

Biocontainment systems that couple environmental sensing with circuit-based control of cell viability could be used to prevent escape of genetically modified microbes into the environment. Here we present two engineered safe-guard systems: the Deadman and Passcode kill switches. The Deadman kill swi...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Chan, Clement T. Y., Lee, Jeong Wook, Cameron, D. Ewen, Bashor, Caleb J., Collins, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718764/
https://ncbi.nlm.nih.gov/pubmed/26641934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1979
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