Pyrin Inflammasome Activation and RhoA Signaling in the Autoinflammatory Diseases FMF and HIDS

Por Park, Yong Hwan, Wood, Geryl, Kastner, Daniel L., Chae, Jae Jin
Publicado no Nat Immunol (2016)

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production

Por Chae, Jae Jin, Wood, Geryl, Masters, Seth L., Richard, Katharina, Park, Grace, Smith, Brian J., Kastner, Daniel L.
Publicado em 2006

The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis

Por Dumas, Aline, Amiable, Nathalie, de Rivero Vaccari, Juan Pablo, Chae, Jae Jin, Keane, Robert W., Lacroix, Steve, Vallières, Luc
Publicado em 2014

Familial Mediterranean fever presenting as fever of unknown origin in Korea

Por Lee, Jun Hee, Kim, Jong Hyun, Shim, Jung Ok, Lee, Kwang Chul, Lee, Joo Won, Lee, Jung Hwa, Chae, Jae Jin
Publicado no Korean J Pediatr (2016)

Gain-of-function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

Por Chae, Jae Jin, Cho, Young-Hun, Lee, Geun-Shik, Cheng, Jun, Liu, P. Paul, Feigenbaum, Lionel, Katz, Stephen I., Kastner, Daniel L.
Publicado em 2011

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

Por Chung, Lawton K., Park, Yong Hwan, Zheng, Yueting, Brodsky, Igor E., Hearing, Patrick, Kastner, Daniel L., Chae, Jae Jin, Bliska, James B.
Publicado no Cell Host Microbe (2016)

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-κB through its N-terminal fragment

Por Chae, Jae Jin, Wood, Geryl, Richard, Katharina, Jaffe, Howard, Colburn, Nona T., Masters, Seth L., Gumucio, Deborah L., Shoham, Nitza G., Kastner, Daniel L.
Publicado em 2008

Sexual dimorphism in immune response genes as a function of puberty

Por Lamason, Rebecca, Zhao, Po, Rawat, Rashmi, Davis, Adrian, Hall, John C, Chae, Jae Jin, Agarwal, Rajeev, Cohen, Phillip, Rosen, Antony, Hoffman, Eric P, Nagaraju, Kanneboyina
Publicado em 2006

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca(2+) and cAMP

Por Lee, Geun-Shik, Subramanian, Naeha, Kim, Andrew I., Aksentijevich, Ivona, Goldbach-Mansky, Raphaela, Sacks, David B., Germain, Ronald N., Kastner, Daniel L., Chae, Jae Jin
Publicado em 2012

Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages

Por Aflaki, Elma, Moaven, Nima, Borger, Daniel K., Lopez, Grisel, Westbroek, Wendy, Chae, Jae Jin, Marugan, Juan, Patnaik, Samarjit, Maniwang, Emerson, Gonzalez, Ashley N., Sidransky, Ellen
Publicado no Aging Cell (2015)

Familial Mediterranean fever with a single MEFV mutation: Where is the second hit?

Por Booty, Matthew G., Chae, Jae Jin, Masters, Seth L., Remmers, Elaine F., Barham, Beverly, Lee, Julie M., Barron, Karyl S., Holland, Steve, Kastner, Daniel L., Aksentijevich, Ivona
Publicado em 2009

Prostaglandin E(2) inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cAMP in human macrophages

Por Sokolowska, Milena, Chen, Li-Yuan, Liu, Yueqin, Martinez-Anton, Asuncion, Qi, Hai-Yan, Logun, Carolea, Alsaaty, Sara, Park, Yong Hwan, Kastner, Daniel L., Chae, Jae Jin, Shelhamer, James H.
Publicado no J Immunol (2015)

Microarray-based gene expression profiling in patients with cryopyrin-associated periodic syndromes defines a disease-related signature and IL-1-responsive transcripts

Por Balow, James E, Ryan, John G, Chae, Jae Jin, Booty, Matthew G, Bulua, Ariel, Stone, Deborah, Sun, Hong-Wei, Greene, James, Barham, Beverly, Goldbach-Mansky, Raphaela, Kastner, Daniel L, Aksentijevich, Ivona
Publicado em 2012

Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome

Por Simon, Anna, Park, Heiyoung, Maddipati, Ravikanth, Lobito, Adrian A., Bulua, Ariel C., Jackson, Adrianna J., Chae, Jae Jin, Ettinger, Rachel, de Koning, Heleen D., Cruz, Anthony C., Kastner, Daniel L., Komarow, Hirsh, Siegel, Richard M.
Publicado em 2010

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β

Por Kim, Man Lyang, Chae, Jae Jin, Park, Yong Hwan, De Nardo, Dominic, Stirzaker, Roslynn A., Ko, Hyun-Ja, Tye, Hazel, Cengia, Louise, DiRago, Ladina, Metcalf, Donald, Roberts, Andrew W., Kastner, Daniel L., Lew, Andrew M., Lyras, Dena, Kile, Benjamin T., Croker, Ben A., Masters, Seth L.
Publicado no J Exp Med (2015)

Control of the innate immune response by the mevalonate pathway

Por Akula, Murali K., Shi, Man, Jiang, Zhaozhao, Foster, Celia E., Miao, David, Li, Annie S., Zhang, Xiaoman, Gavin, Ruth M., Forde, Sorcha D., Germain, Gail, Carpenter, Susan, Rosadini, Charles V., Gritsman, Kira, Chae, Jae Jin, Hampton, Randolph, Silverman, Neal, Gravallese, Ellen M., Kagan, Jonathan C., Fitzgerald, Katherine A., Kastner, Daniel L., Golenbock, Douglas T., Bergo, Martin O., Wang, Donghai
Publicado no Nat Immunol (2016)

A small molecule inhibitior of the NLRP3 inflammasome is a potential therapeutic for inflammatory diseases

Por Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stutz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., O’Neill, Luke A. J.
Publicado no Nat Med (2015)

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

Por Zhou, Qing, Yu, Xiaomin, Demirkaya, Erkan, Deuitch, Natalie, Stone, Deborah, Tsai, Wanxia Li, Kuehn, Hye Sun, Wang, Hongying, Yang, Dan, Park, Yong Hwan, Ombrello, Amanda K., Blake, Mary, Romeo, Tina, Remmers, Elaine F., Chae, Jae Jin, Mullikin, James C., Güzel, Ferhat, Milner, Joshua D., Boehm, Manfred, Rosenzweig, Sergio D., Gadina, Massimo, Welch, Steven B., Özen, Seza, Topaloglu, Rezan, Abinun, Mario, Kastner, Daniel L., Aksentijevich, Ivona
Publicado no Proc Natl Acad Sci U S A (2016)

De Novo CIAS1 Mutations, Cytokine Activation, and Evidence for Genetic Heterogeneity in Patients With Neonatal-Onset Multisystem Inflammatory Disease (NOMID): A New Member of the E...

Por Aksentijevich, Ivona, Nowak, Miroslawa, Mallah, Mustapha, Chae, Jae Jin, Watford, Wendy T., Hofmann, Sigrun R., Stein, Leonard, Russo, Ricardo, Goldsmith, Donald, Dent, Peter, Rosenberg, Helene F., Austin, Frances, Remmers, Elaine F., Balow, James E., Rosenzweig, Sergio, Komarow, Hirsh, Shoham, Nitza G., Wood, Geryl, Jones, Janet, Mangra, Nadira, Carrero, Hector, Adams, Barbara S., Moore, Terry L., Schikler, Kenneth, Hoffman, Hal, Lovell, Daniel J., Lipnick, Robert, Barron, Karyl, O’Shea, John J, Kastner, Daniel L., Goldbach-Mansky, Raphaela
Publicado no Arthritis Rheum (2002)

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production

Por Brehm, Anja, Liu, Yin, Sheikh, Afzal, Marrero, Bernadette, Omoyinmi, Ebun, Zhou, Qing, Montealegre, Gina, Biancotto, Angelique, Reinhardt, Adam, Almeida de Jesus, Adriana, Pelletier, Martin, Tsai, Wanxia L., Remmers, Elaine F., Kardava, Lela, Hill, Suvimol, Kim, Hanna, Lachmann, Helen J., Megarbane, Andre, Chae, Jae Jin, Brady, Jilian, Castillo, Rhina D., Brown, Diane, Casano, Angel Vera, Gao, Ling, Chapelle, Dawn, Huang, Yan, Stone, Deborah, Chen, Yongqing, Sotzny, Franziska, Lee, Chyi-Chia Richard, Kastner, Daniel L., Torrelo, Antonio, Zlotogorski, Abraham, Moir, Susan, Gadina, Massimo, McCoy, Phil, Wesley, Robert, Rother, Kristina, Hildebrand, Peter W., Brogan, Paul, Krüger, Elke, Aksentijevich, Ivona, Goldbach-Mansky, Raphaela
Publicado no J Clin Invest (2015)