Prostaglandin E(2) inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cAMP in human macrophages

Prostaglandin E(2) (PGE(2)) is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and cancer. NLRP3 inflammasome plays an important role in host defense. Uncontrolled activation of NLRP3 inflammasome, due...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Sokolowska, Milena, Chen, Li-Yuan, Liu, Yueqin, Martinez-Anton, Asuncion, Qi, Hai-Yan, Logun, Carolea, Alsaaty, Sara, Park, Yong Hwan, Kastner, Daniel L., Chae, Jae Jin, Shelhamer, James H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433768/
https://ncbi.nlm.nih.gov/pubmed/25917098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401343
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