Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A(2)α and Eicosanoid Production in Monocytes and Macrophages

Hyaluronan (HA) is the major glycosaminoglycan in the extracellular matrix. During inflammation, there is an increased breakdown of HA, resulting in the accumulation of low molecular weight (LMW) HA and activation of monocytes and macrophages. Eicosanoids, derived from the cytosolic phospholipase A(...

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Hlavní autoři: Sokolowska, Milena, Chen, Li-Yuan, Eberlein, Michael, Martinez-Anton, Asuncion, Liu, Yueqin, Alsaaty, Sara, Qi, Hai-Yan, Logun, Carolea, Horton, Maureen, Shelhamer, James H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924308/
https://ncbi.nlm.nih.gov/pubmed/24366870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515106
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