Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages

Gaucher disease, the inherited deficiency of lysosomal glucocerebrosidase, is characterized by the presence of glucosylcer‐amide macrophages, the accumulation of glucosylceramide in lysosomes and the secretion of inflammatory cytokines. However, the connection between this lysosomal storage and infl...

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Vydáno v:Aging Cell
Hlavní autoři: Aflaki, Elma, Moaven, Nima, Borger, Daniel K., Lopez, Grisel, Westbroek, Wendy, Chae, Jae Jin, Marugan, Juan, Patnaik, Samarjit, Maniwang, Emerson, Gonzalez, Ashley N., Sidransky, Ellen
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717273/
https://ncbi.nlm.nih.gov/pubmed/26486234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12409
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