Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages

Gaucher disease, the inherited deficiency of lysosomal glucocerebrosidase, is characterized by the presence of glucosylcer‐amide macrophages, the accumulation of glucosylceramide in lysosomes and the secretion of inflammatory cytokines. However, the connection between this lysosomal storage and infl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Aflaki, Elma, Moaven, Nima, Borger, Daniel K., Lopez, Grisel, Westbroek, Wendy, Chae, Jae Jin, Marugan, Juan, Patnaik, Samarjit, Maniwang, Emerson, Gonzalez, Ashley N., Sidransky, Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717273/
https://ncbi.nlm.nih.gov/pubmed/26486234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12409
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados