A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

Among the known genetic risk factors for Parkinson disease, mutations in GBA1, the gene responsible for the lysosomal disorder Gaucher disease, are the most common. This genetic link has directed attention to the role of the lysosome in the pathogenesis of parkinsonism. To study how glucocerebrosida...

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Udgivet i:J Neurosci
Main Authors: Aflaki, Elma, Borger, Daniel K., Moaven, Nima, Stubblefield, Barbara K., Rogers, Steven A., Patnaik, Samarjit, Schoenen, Frank J., Westbroek, Wendy, Zheng, Wei, Sullivan, Patricia, Fujiwara, Hideji, Sidhu, Rohini, Khaliq, Zayd M, Lopez, Grisel J., Goldstein, David S., Ory, Daniel S., Marugan, Juan, Sidransky, Ellen
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945664/
https://ncbi.nlm.nih.gov/pubmed/27413154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0636-16.2016
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