A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

Among the known genetic risk factors for Parkinson disease, mutations in GBA1, the gene responsible for the lysosomal disorder Gaucher disease, are the most common. This genetic link has directed attention to the role of the lysosome in the pathogenesis of parkinsonism. To study how glucocerebrosida...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Neurosci
Autors principals: Aflaki, Elma, Borger, Daniel K., Moaven, Nima, Stubblefield, Barbara K., Rogers, Steven A., Patnaik, Samarjit, Schoenen, Frank J., Westbroek, Wendy, Zheng, Wei, Sullivan, Patricia, Fujiwara, Hideji, Sidhu, Rohini, Khaliq, Zayd M, Lopez, Grisel J., Goldstein, David S., Ory, Daniel S., Marugan, Juan, Sidransky, Ellen
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2016
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945664/
https://ncbi.nlm.nih.gov/pubmed/27413154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0636-16.2016
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars