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Macrophage Models of Gaucher Disease for Evaluating Disease Pathogenesis and Candidate Drugs
Gaucher disease is caused by an inherited deficiency of glucocerebrosidase that manifests with storage of glycolipids in lysosomes, particularly in macrophages. Available cell lines modeling Gaucher disease do not demonstrate lysosomal storage of glycolipids; therefore, we set out to develop two mac...
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| Autors principals: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4161206/ https://ncbi.nlm.nih.gov/pubmed/24920659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008659 |
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