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Macrophage Models of Gaucher Disease for Evaluating Disease Pathogenesis and Candidate Drugs

Gaucher disease is caused by an inherited deficiency of glucocerebrosidase that manifests with storage of glycolipids in lysosomes, particularly in macrophages. Available cell lines modeling Gaucher disease do not demonstrate lysosomal storage of glycolipids; therefore, we set out to develop two mac...

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Detalhes bibliográficos
Main Authors: Aflaki, Elma, Stubblefield, Barbara K., Maniwang, Emerson, Lopez, Grisel, Moaven, Nima, Goldin, Ehud, Marugan, Juan, Patnaik, Samarjit, Dutra, Amalia, Southall, Noel, Zheng, Wei, Tayebi, Nahid, Sidransky, Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161206/
https://ncbi.nlm.nih.gov/pubmed/24920659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008659
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