Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome

TNF, acting through p55 tumor necrosis factor receptor 1 (TNFR1), contributes to the pathogenesis of many inflammatory diseases. TNFR-associated periodic syndrome (TRAPS, OMIM 142680) is an autosomal dominant autoinflammatory disorder characterized by prolonged attacks of fevers, peritonitis, and so...

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Main Authors: Simon, Anna, Park, Heiyoung, Maddipati, Ravikanth, Lobito, Adrian A., Bulua, Ariel C., Jackson, Adrianna J., Chae, Jae Jin, Ettinger, Rachel, de Koning, Heleen D., Cruz, Anthony C., Kastner, Daniel L., Komarow, Hirsh, Siegel, Richard M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906866/
https://ncbi.nlm.nih.gov/pubmed/20457915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914118107
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