Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

Reactive oxygen species (ROS) have an established role in inflammation and host defense, as they kill intracellular bacteria and have been shown to activate the NLRP3 inflammasome. Here, we find that ROS generated by mitochondrial respiration are important for normal lipopolysaccharide (LPS)-driven...

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Detalhes bibliográficos
Main Authors: Bulua, Ariel C., Simon, Anna, Maddipati, Ravikanth, Pelletier, Martin, Park, Heiyoung, Kim, Kye-Young, Sack, Michael N., Kastner, Daniel L., Siegel, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058571/
https://ncbi.nlm.nih.gov/pubmed/21282379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20102049
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