Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

Reactive oxygen species (ROS) have an established role in inflammation and host defense, as they kill intracellular bacteria and have been shown to activate the NLRP3 inflammasome. Here, we find that ROS generated by mitochondrial respiration are important for normal lipopolysaccharide (LPS)-driven...

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Détails bibliographiques
Auteurs principaux: Bulua, Ariel C., Simon, Anna, Maddipati, Ravikanth, Pelletier, Martin, Park, Heiyoung, Kim, Kye-Young, Sack, Michael N., Kastner, Daniel L., Siegel, Richard M.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058571/
https://ncbi.nlm.nih.gov/pubmed/21282379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20102049
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