Role of Aldo–Keto Reductase Enzymes in Mediating the Timing of Parturition

Por Byrns, Michael C.
Publicado em 2012

Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase (AKR1C3): Role In Breast Cancer and Inhibition by Nonsteroidal Antiinflammatory Drug Analogs

Por Byrns, Michael C., Penning, Trevor M.
Publicado em 2008

Steroid Hormone Transforming Aldo-Keto Reductases and Cancer

Por Penning, Trevor M., Byrns, Michael C.
Publicado em 2009

An Indomethacin Analogue, N-(4-Chlorobenzoyl)-melatonin, is a Selective Inhibitor of Aldo-keto Reductase 1C3 (Type 2 3α-HSD, Type 5 17β-HSD, and Prostaglandin F Synthase), a Potent...

Por Byrns, Michael C., Steckelbroeck, Stephan, Penning, Trevor M.
Publicado em 2007

Inhibitors of Type 5 17β-Hydroxysteroid Dehydrogenase (AKR1C3): Overview and Structural Insights

Por Byrns, Michael C., Jin, Yi, Penning, Trevor M.
Publicado em 2010

Overexpression of Aldo-Keto Reductase 1C3 (AKR1C3) in LNCaP Cells Diverts Androgen Metabolism towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride...

Por Byrns, Michael C., Mindnich, Rebekka, Duan, Ling, Penning, Trevor M.
Publicado em 2012

Formation of 1,4-dioxo-2-butene-derived adducts of 2′-deoxyadenosine and 2′-deoxycytosine in oxidized DNA

Por Chen, Bingzi, Vu, Choua C., Byrns, Michael C., Dedon, Peter C., Peterson, Lisa A.
Publicado em 2006

Aldo-Keto Reductase 1C3 Expression in MCF-7 Cells Reveals Roles in Steroid Hormone and Prostaglandin Metabolism that may Explain its Over-Expression in Breast Cancer

Por Byrns, Michael C., Duan, Ling, Lee, Seon Hwa, Blair, Ian A., Penning, Trevor M.
Publicado em 2009

Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)

Por Adeniji, Adegoke O., Twenter, Barry M., Byrns, Michael C., Jin, Yi, Winkler, Jeffrey D., Penning, Trevor M.
Publicado em 2011

Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial

Por Byrns, Michael C., Vu, Choua C., Neidigh, Jonathan W., Abad, José-Luis, Jones, Roger A., Peterson, Lisa A.
Publicado em 2006

Development of Potent and Selective Inhibitors of Aldo-Keto Reductase 1C3 (type 5 17β-Hydroxysteroid Dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure Activity Re...

Por Adeniji, Adegoke O., Twenter, Barry M., Byrns, Michael C., Jin, Yi, Chen, Mo, Winkler, Jeffrey D., Penning, Trevor M.
Publicado em 2012

Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Pro...

Por Liedtke, Andy J., Adeniji, Adegoke O., Chen, Mo, Byrns, Michael C., Jin, Yi, Christianson, David W., Marnett, Lawrence J., Penning, Trevor M.
Publicado em 2013

Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS...

Por Tamae, Daniel, Byrns, Michael, Marck, Brett, Mostaghel, Elahe A., Nelson, Peter S., Lange, Paul, Lin, Daniel, Taplin, Mary-Ellen, Balk, Steven, Ellis, William, True, Larry, Vessella, Robert, Montgomery, Bruce, Blair, Ian A., Penning, Trevor M.
Publicado em 2013