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Aldo-Keto Reductase 1C3 Expression in MCF-7 Cells Reveals Roles in Steroid Hormone and Prostaglandin Metabolism that may Explain its Over-Expression in Breast Cancer

Aldo-keto reductase (AKR) 1C3 (type 5 17β-hydroxysteroid dehydrogenase and prostaglandin F synthase), may stimulate proliferation via steroid hormone and prostaglandin (PG) metabolism in the breast. Purified recombinant AKR1C3 reduces PGD(2) to 9α,11β-PGF(2), Δ(4)-androstenedione to testosterone, pr...

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Detalhes bibliográficos
Main Authors: Byrns, Michael C., Duan, Ling, Lee, Seon Hwa, Blair, Ian A., Penning, Trevor M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819162/
https://ncbi.nlm.nih.gov/pubmed/20036328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2009.12.009
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