Caricamento...

Overexpression of Aldo-Keto Reductase 1C3 (AKR1C3) in LNCaP Cells Diverts Androgen Metabolism towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

Type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) is the major enzyme in the prostate that reduces 4-androstene-3,17-dione (Δ(4)-Adione) to the androgen receptor (AR) ligand testosterone. AKR1C3 is upregulated in prostate cancer (PCa) and castrate resistant prostate cancer (CRPC) that develops after...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Byrns, Michael C., Mindnich, Rebekka, Duan, Ling, Penning, Trevor M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319280/
https://ncbi.nlm.nih.gov/pubmed/22265960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2011.12.012
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !