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Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review

INTRODUCTION: AKR1C3 is a drug target in hormonal and hormonal independent malignancies and acts as a major peripheral 17β-hydroxysteroid dehydrogenase to yield the potent androgens testosterone and dihydrotestosterone, and as a prostaglandin (PG) F synthase to produce proliferative ligands for the...

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Publicado en:Expert Opin Ther Pat
Autor principal: Penning, Trevor M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724044/
https://ncbi.nlm.nih.gov/pubmed/28895472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13543776.2017.1379503
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