N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo–keto reductase AKR1C3

Human aldo–keto reductases AKR1C1–AKR1C3 are involved in the biosynthesis and inactivation of steroid hormones and prostaglandins and thus represent attractive targets for the development of new drugs. We synthesized a series of N-benzoyl anthranilic acid derivatives and tested their inhibitory acti...

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Main Authors: Sinreih, Maša, Sosič, Izidor, Beranič, Nataša, Turk, Samo, Adeniji, Adegoke O., Penning, Trevor M., Rižner, Tea Lanišnik, Gobec, Stanislav
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038446/
https://ncbi.nlm.nih.gov/pubmed/22897946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.07.062
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