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Selective Inhibitors of Aldo-Keto Reductases AKR1C1 and AKR1C3 Discovered by Virtual Screening of a Fragment Library
Human aldo-keto reductases 1C1-1C4 (AKR1C1-AKR1C4) function in vivo as 3-keto-, 17-keto- and 20- ketosteroid reductases, and regulate the activity of androgens, estrogens and progesterone and the occupancy and transactivation of their corresponding receptors. Aberrant expression and action of AKR1C...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3470935/ https://ncbi.nlm.nih.gov/pubmed/22881866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300841n |
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