Selective Inhibitors of Aldo-Keto Reductases AKR1C1 and AKR1C3 Discovered by Virtual Screening of a Fragment Library

Human aldo-keto reductases 1C1-1C4 (AKR1C1-AKR1C4) function in vivo as 3-keto-, 17-keto- and 20- ketosteroid reductases, and regulate the activity of androgens, estrogens and progesterone and the occupancy and transactivation of their corresponding receptors. Aberrant expression and action of AKR1C...

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Hlavní autoři: Brožič, Petra, Turk, Samo, Adeniji, Adegoke O., Konc, Janez, Janežič, Dušanka, Penning, Trevor M., Rižner, Tea Lanišnik, Gobec, Stanislav
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470935/
https://ncbi.nlm.nih.gov/pubmed/22881866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300841n
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