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Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase (AKR1C3): Role In Breast Cancer and Inhibition by Nonsteroidal Antiinflammatory Drug Analogs
Aldo-keto reductase (AKR) 1C3 catalyzes the NADPH dependent reduction of Δ(4)-androstene-3,17-dione to yield testosterone, reduction of estrone to yield 17β-estradiol and reduction of progesterone to yield 20α-hydroxyprogesterone. In addition, it functions as a prostaglandin (PG) F synthase and redu...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076957/ https://ncbi.nlm.nih.gov/pubmed/19010312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2008.10.024 |
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