Screening Baccharin Analogs as Selective Inhibitors Against Type 5 17β-Hydroxysteroid Dehydrogenase (AKR1C3)

Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17β-hydroxysteroid dehydrogenase, is a downstream steroidogenic enzyme and converts androgen precursors to the potent androgen receptor ligands: testosterone and 5α-dihydrotestosterone. Studies have shown that AKR1C3 is involved in the developme...

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Bibliographische Detailangaben
Veröffentlicht in:Chem Biol Interact
Hauptverfasser: Zang, Tianzhu, Verma, Kshitij, Chen, Mo, Jin, Yi, Trippier, Paul C., Penning, Trevor M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414711/
https://ncbi.nlm.nih.gov/pubmed/25555457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2014.12.015
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