Synthesis and biological evaluation of 12-N-p-chlorobenzyl sophoridinol derivatives as a novel family of anticancer agents

Por Bi, Chongwen, Ye, Cheng, Li, Yinghong, Zhao, Wuli, Shao, Rongguang, Song, Danqing
Publicado no Acta Pharm Sin B (2016)

Sophoridinol derivative 05D induces tumor cells apoptosis by topoisomerase1-mediated DNA breakage

Por Zhao, Wuli, Zhang, Caixia, Bi, Chongwen, Ye, Cheng, Song, Danqing, Liu, Xiujun, Shao, Rongguang
Publicado no Onco Targets Ther (2016)

IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1α and PERK signaling

Por Zhang, Na, Bi, Chongwen, Liu, Lu, Dou, Yueying, Tang, Sheng, Pang, Weiqiang, Deng, Hongbin, Song, Danqing
Publicado no Oncotarget (2016)

Synthesis and Biological Evaluation of Sophoridinol Derivatives as a Novel Family of Potential Anticancer Agents

Por Bi, Chongwen, Zhang, Caixia, Li, Yinghong, Tang, Sheng, Wang, Shenggang, Shao, Rongguang, Fu, Haigen, Su, Feng, Song, Danqing
Publicado no ACS Med Chem Lett (2014)

Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells

Por Liu, Lu, Zhang, Na, Dou, Yueying, Mao, Genxiang, Bi, Chongwen, Pang, Weiqiang, Liu, Xiaojia, Song, Danqing, Deng, Hongbin
Publicado no Sci Rep (2017)

Synthesis, Biological Evaluation, and Autophagy Mechanism of 12N-Substituted Sophoridinamines as Novel Anticancer Agents

Por Bi, Chongwen, Zhang, Na, Yang, Peng, Ye, Cheng, Wang, Yanxiang, Fan, Tianyun, Shao, Rongguang, Deng, Hongbin, Song, Danqing
Publicado no ACS Med Chem Lett (2017)

The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2α by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation

Por Zhao, Wuli, Jiang, Guohua, Bi, Chongwen, Li, Yangbiao, Liu, Jingbo, Ye, Cheng, He, Hongwei, Li, Liang, Song, Danqing, Shao, Rongguang
Publicado no Oncotarget (2015)