The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2α by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation

DNA topoisomerases play a key role in tumor proliferation. Chemotherapeutics targeting topoisomerases have been widely used in clinical oncology, but resistance and side effects, particularly cardiotoxicity, usually limit their application. Clinical data show that a decrease in topoisomerase (top) l...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhao, Wuli, Jiang, Guohua, Bi, Chongwen, Li, Yangbiao, Liu, Jingbo, Ye, Cheng, He, Hongwei, Li, Liang, Song, Danqing, Shao, Rongguang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741971/
https://ncbi.nlm.nih.gov/pubmed/26462155
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