Sophoridinol derivative 05D induces tumor cells apoptosis by topoisomerase1-mediated DNA breakage

Sophoridine is a quinolizidine natural product of Sophora alopecuroides and has been applied for treatment of malignant trophoblastic tumors. Although characterized by low toxicity, the limited-spectrum antitumor activity hinders its further applications. 05D, a derivative of sophoridine, exhibits a...

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Vydáno v:Onco Targets Ther
Hlavní autoři: Zhao, Wuli, Zhang, Caixia, Bi, Chongwen, Ye, Cheng, Song, Danqing, Liu, Xiujun, Shao, Rongguang
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2016
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869659/
https://ncbi.nlm.nih.gov/pubmed/27274276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S103671
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