載入...
The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation
Sophoridine is a quinolizidine natural product and the exploration of its derivatives has been carried out, and the potent anticancer compound IMB-HDC was acquired. Although previous studies have revealed that some sophoridine derivatives could induce DNA breakage, the underlying mechanisms of inhib...
Na minha lista:
| 發表在: | Acta Pharmacol Sin |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer Singapore
2020
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7471404/ https://ncbi.nlm.nih.gov/pubmed/31932645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0333-6 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|