Histone modifications predispose genome regions to breakage and translocation

Chromosome translocations are well-established hallmarks of cancer cells and often occur at nonrandom sites in the genome. The molecular features that define recurrent chromosome breakpoints are largely unknown. Using a combination of bioinformatics, biochemical analysis, and cell-based assays, we i...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Burman, Bharat, Zhang, Zhuzhu Z., Pegoraro, Gianluca, Lieb, Jason D., Misteli, Tom
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511214/
https://ncbi.nlm.nih.gov/pubmed/26104467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.262170.115
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