Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation

Type II topoisomerases resolve topological problems of DNA double helices by passing one duplex through the reversible double-stranded break they generated on another duplex. Despite the wealth of information in the cleaving operation, molecular understanding of the enzymatic DNA ligation remains el...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Huang, Nan-Lan, Lin, Jung-Hsin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Computational Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538842/
https://ncbi.nlm.nih.gov/pubmed/26150421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv672
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