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A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism
The different steps of the human Top1 (topoisomerase I) catalytic cycle have been analysed in the presence of a pentacyclic-diquinoid synthetic compound. The experiments indicate that it efficiently inhibits the cleavage step of the enzyme reaction, fitting well into the catalytic site. Surprisingly...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3590572/ https://ncbi.nlm.nih.gov/pubmed/23368812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120118 |
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