A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism

The different steps of the human Top1 (topoisomerase I) catalytic cycle have been analysed in the presence of a pentacyclic-diquinoid synthetic compound. The experiments indicate that it efficiently inhibits the cleavage step of the enzyme reaction, fitting well into the catalytic site. Surprisingly...

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Detalhes bibliográficos
Main Authors: Arnò, Barbara, Coletta, Andrea, Tesauro, Cinzia, Zuccaro, Laura, Fiorani, Paola, Lentini, Sara, Galloni, Pierluca, Conte, Valeria, Floris, Barbara, Desideri, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2013
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590572/
https://ncbi.nlm.nih.gov/pubmed/23368812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120118
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