Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico

BACKGROUND: DNA topoisomerases are key enzymes that modulate the topological state of DNA through the breaking and rejoining of DNA strands. Human topoisomerase IB can be inhibited by several compounds that act through different mechanisms, including clinically used drugs, such as the derivatives of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tesauro, Cinzia, Morozzo della Rocca, Blasco, Ottaviani, Alessio, Coletta, Andrea, Zuccaro, Laura, Arnò, Barbara, D'Annessa, Ilda, Fiorani, Paola, Desideri, Alessandro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2013
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766703/
https://ncbi.nlm.nih.gov/pubmed/24004603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-100
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