Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico

BACKGROUND: DNA topoisomerases are key enzymes that modulate the topological state of DNA through the breaking and rejoining of DNA strands. Human topoisomerase IB can be inhibited by several compounds that act through different mechanisms, including clinically used drugs, such as the derivatives of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tesauro, Cinzia, Morozzo della Rocca, Blasco, Ottaviani, Alessio, Coletta, Andrea, Zuccaro, Laura, Arnò, Barbara, D'Annessa, Ilda, Fiorani, Paola, Desideri, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766703/
https://ncbi.nlm.nih.gov/pubmed/24004603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-100
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados