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A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance
Human DNA topoisomerase I (hTop1p) catalyzes the relaxation of supercoiled DNA and constitutes the cellular target of the antitumor drug camptothecin (CPT). The X-ray crystal structure of the enzyme covalently joined to DNA and bound to the CPT analog Topotecan suggests that there are two classes of...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2553582/ https://ncbi.nlm.nih.gov/pubmed/18772225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn557 |
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