A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance

Human DNA topoisomerase I (hTop1p) catalyzes the relaxation of supercoiled DNA and constitutes the cellular target of the antitumor drug camptothecin (CPT). The X-ray crystal structure of the enzyme covalently joined to DNA and bound to the CPT analog Topotecan suggests that there are two classes of...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Losasso, Carmen, Cretaio, Erica, Fiorani, Paola, D’Annessa, Ilda, Chillemi, Giovanni, Benedetti, Piero
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553582/
https://ncbi.nlm.nih.gov/pubmed/18772225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn557
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky