Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells

Targeting the autophagic pathway is currently regarded as an attractive strategy for cancer drug discovery. Our previous work showed that IMB-6G is a novel N-substituted sophoridinic acid derivative with potent cytotoxicity against tumor cells, yet the effect of IMB-6G on autophagy and pancreatic ca...

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Publicado no:Sci Rep
Main Authors: Liu, Lu, Zhang, Na, Dou, Yueying, Mao, Genxiang, Bi, Chongwen, Pang, Weiqiang, Liu, Xiaojia, Song, Danqing, Deng, Hongbin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282566/
https://ncbi.nlm.nih.gov/pubmed/28139733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41862
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