Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIP(L) in hepatocellular carcinoma

Glycogen synthase kinase-3β (GSK-3β) is a ubiquitously expressed serine/threonine kinase involved in a variety of functions ranging from the control of glycogen metabolism to transcriptional regulation. We recently demonstrated that GSK-3β inhibition triggered ASK1-JNK-dependent apoptosis in human h...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhang, Na, Liu, Xiaojia, Liu, Lu, Deng, Zhesong, Zeng, Qingxuan, Pang, Weiqiang, Liu, Yang, Song, Danqing, Deng, Hongbin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833564/
https://ncbi.nlm.nih.gov/pubmed/29445085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0309-3
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