Probing Conformational Rescue Induced by a Chemical Corrector of F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutant

Por Yu, Wilson, Chiaw, Patrick Kim, Bear, Christine E.
Publicado em 2011

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein

Por Eckford, Paul D. W., Li, Canhui, Bear, Christine E.
Publicado no J Vis Exp (2015)

Evaluation of the membrane-spanning domain of ClC-2

Por Ramjeesingh, Mohabir, Li, Canhui, She, Yi-Min, Bear, Christine E.
Publicado em 2006

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-ind...

Por Eckford, Paul D. W., Li, Canhui, Ramjeesingh, Mohabir, Bear, Christine E.
Publicado em 2012

Dimeric cystic fibrosis transmembrane conductance regulator exists in the plasma membrane.

Por Ramjeesingh, Mohabir, Kidd, Jackie F, Huan, Ling Jun, Wang, Yanchun, Bear, Christine E
Publicado em 2003

Evidence for a Superoxide Permeability Pathway in Endosomal Membranes

Por Mumbengegwi, Davis R., Li, Qiang, Li, Canhui, Bear, Christine E., Engelhardt, John F.
Publicado em 2008

ATP Induces Conformational Changes in the Carboxyl-terminal Region of ClC-5

Por Wellhauser, Leigh, Luna-Chavez, Cesar, D'Antonio, Christina, Tainer, John, Bear, Christine E.
Publicado em 2011

The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1–NBD2 heterodimer

Por Stratford, Fiona L. L., Ramjeesingh, Mohabir, Cheung, Joanne C., Huan, Ling-JUN, Bear, Christine E.
Publicado em 2006

Functional Rescue of F508del-CFTR Using Small Molecule Correctors

Por Molinski, Steven, Eckford, Paul D. W., Pasyk, Stan, Ahmadi, Saumel, Chin, Stephanie, Bear, Christine E.
Publicado em 2012

Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore.

Por Ramjeesingh, Mohabir, Ugwu, Francisca, Li, Canhui, Dhani, Sonja, Huan, Ling Jun, Wang, Yanchun, Bear, Christine E
Publicado em 2003

The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor

Por Broadbent, Steven D., Ramjeesingh, Mohabir, Bear, Christine E., Argent, Barry E., Linsdell, Paul, Gray, Michael A.
Publicado no Pflugers Arch (2014)

Proton-Dependent Gating and Proton Uptake by Wzx Support O-Antigen-Subunit Antiport Across the Bacterial Inner Membrane

Por Islam, Salim T., Eckford, Paul D. W., Jones, Michelle L., Nugent, Timothy, Bear, Christine E., Vogel, Christian, Lam, Joseph S.
Publicado em 2013

Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface

Por Chin, Stephanie, Yang, Donghe, Miles, Andrew J., Eckford, Paul D. W., Molinski, Steven, Wallace, B. A., Bear, Christine E.
Publicado no J Biol Chem (2017)

CFTR directly mediates nucleotide-regulated glutathione flux

Por Kogan, Ilana, Ramjeesingh, Mohabir, Li, Canhui, Kidd, Jackie F., Wang, Yanchun, Leslie, Elaine M., Cole, Susan P.C., Bear, Christine E.
Publicado em 2003

Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Scie...

Por Verkman, Alan S., Edelman, Aleksander, Amaral, Margarida, Mall, Marcus A., Beekman, Jeffrey M., Meiners, Torsten, Galietta, Luis J.V., Bear, Christine E.
Publicado no J Cyst Fibros (2015)

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

Por Wong, Amy P., Bear, Christine E., Chin, Stephanie, Pasceri, Peter, Thompson, Tadeo O., Huan, Ling-Jun, Ratjen, Felix, Ellis, James, Rossant, Janet
Publicado em 2012

SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

Por Ahmadi, Saumel, Xia, Sunny, Wu, Yu-Sheng, Di Paola, Michelle, Kissoon, Randolph, Luk, Catherine, Lin, Fan, Du, Kai, Rommens, Johanna, Bear, Christine E
Publicado no eLife (2018)

Nucleotides bind to the C-terminus of ClC-5

Por Wellhauser, Leigh, Kuo, Hsin-Hen, Stratford, Fiona L. L., Ramjeesingh, Mohabir, Huan, Ling-Jun, Luong, Winnie, Li, Canhui, Deber, Charles M., Bear, Christine E.
Publicado em 2006

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity

Por Malik, Firhan A., Meissner, Anja, Semenkov, Illya, Molinski, Steven, Pasyk, Stan, Ahmadi, Saumel, Bui, Hai H., Bear, Christine E., Lidington, Darcy, Bolz, Steffen-Sebastian
Publicado no PLoS One (2015)

Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators

Por Laselva, Onofrio, Marzaro, Giovanni, Vaccarin, Christian, Lampronti, Ilaria, Tamanini, Anna, Lippi, Giuseppe, Gambari, Roberto, Cabrini, Giulio, Bear, Christine E., Chilin, Adriana, Dechecchi, Maria C.
Publicado no Front Pharmacol (2018)