Finding new medicines to fight CF: multiple steps of a success story

Por Amaral, Margarida D
Publicado em 2012

Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin

Por Farinha, Carlos M., Amaral, Margarida D.
Publicado em 2005

Hallmarks of Therapeutic Management of the Cystic Fibrosis Functional Landscape

Por Amaral, Margarida D., Balch, William E.
Publicado no J Cyst Fibros (2015)

What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?

Por Amaral, Margarida D., Quaresma, Margarida C., Pankonien, Ines
Publicado no Int J Mol Sci (2020)

Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response

Por Silva, M. Catarina, Amaral, Margarida D., Morimoto, Richard I.
Publicado em 2013

Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies

Por Clarke, Luka A, Sousa, Lisete, Barreto, Celeste, Amaral, Margarida D
Publicado em 2013

The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hs...

Por Farinha, Carlos M, Nogueira, Paulo, Mendes, Filipa, Penque, Deborah, Amaral, Margarida D
Publicado em 2002

Impact of KLF4 on Cell Proliferation and Epithelial Differentiation in the Context of Cystic Fibrosis

Por Sousa, Luís, Pankonien, Ines, Simões, Filipa B., Chanson, Marc, Amaral, Margarida D.
Publicado no Int J Mol Sci (2020)

Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR

Por Farinha, Carlos M, Sousa, Marisa, Canato, Sara, Schmidt, André, Uliyakina, Inna, Amaral, Margarida D
Publicado no Pharmacol Res Perspect (2015)

KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway

Por Sousa, Luis, Pankonien, Ines, Clarke, Luka A, Silva, Iris, Kunzelmann, Karl, Amaral, Margarida D
Publicado no Cells (2020)

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells

Por Garcia, Susana M., Casanueva, M. Olivia, Silva, M. Catarina, Amaral, Margarida D., Morimoto, Richard I.
Publicado em 2007

Regulation of the Epithelial Na(+) Channel by the Protein Kinase CK2

Por Bachhuber, Tanja, Almaça, Joana, Aldehni, Fadi, Mehta, Anil, Amaral, Margarida D., Schreiber, Rainer, Kunzelmann, Karl
Publicado em 2008

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

Por Silva, M. Catarina, Fox, Susan, Beam, Monica, Thakkar, Happy, Amaral, Margarida D., Morimoto, Richard I.
Publicado em 2011

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant

Por Matos, Ana M., Pinto, Francisco R., Barros, Patrícia, Amaral, Margarida D., Pepperkok, Rainer, Matos, Paulo
Publicado no J Biol Chem (2019)

Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation

Por Pinto, Madalena C., Schreiber, Rainer, Lerias, Joana, Ousingsawat, Jiraporn, Duarte, Aires, Amaral, Margarida, Kunzelmann, Karl
Publicado no Cells (2020)

Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase

Por Mendes, Ana Isabel, Matos, Paulo, Moniz, Sónia, Luz, Simão, Amaral, Margarida D., Farinha, Carlos M., Jordan, Peter
Publicado em 2011

LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells

Por Luz, Simão, Cihil, Kristine M., Brautigan, David L., Amaral, Margarida D., Farinha, Carlos M., Swiatecka-Urban, Agnieszka
Publicado em 2014

A Mathematical Model of the Phosphoinositide Pathway

Por Olivença, Daniel V., Uliyakina, Inna, Fonseca, Luis L., Amaral, Margarida D., Voit, Eberhard O., Pinto, Francisco R.
Publicado no Sci Rep (2018)

Prolonged co-treatment with HGF sustains epithelial integrity and improves pharmacological rescue of Phe508del-CFTR

Por Matos, Ana M., Gomes-Duarte, Andreia, Faria, Márcia, Barros, Patrícia, Jordan, Peter, Amaral, Margarida D., Matos, Paulo
Publicado no Sci Rep (2018)

Deletion of CFTR Translation Start Site Reveals Functional Isoforms of the Protein in CF Patients

Por Ramalho, Anabela S., Lewandowska, Marzena A., Farinha, Carlos M., Mendes, Filipa, Gonçalves, Juan, Barreto, Celeste, Harris, Ann, Amaral, Margarida D.
Publicado em 2009