Finding new medicines to fight CF: multiple steps of a success story

by Amaral, Margarida D
Published 2012

Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin

by Farinha, Carlos M., Amaral, Margarida D.
Published 2005

Hallmarks of Therapeutic Management of the Cystic Fibrosis Functional Landscape

by Amaral, Margarida D., Balch, William E.
Published in J Cyst Fibros (2015)

What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?

by Amaral, Margarida D., Quaresma, Margarida C., Pankonien, Ines
Published in Int J Mol Sci (2020)

Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response

by Silva, M. Catarina, Amaral, Margarida D., Morimoto, Richard I.
Published 2013

Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies

by Clarke, Luka A, Sousa, Lisete, Barreto, Celeste, Amaral, Margarida D
Published 2013

Personalized Medicine Based on Nasal Epithelial Cells: Comparative Studies with Rectal Biopsies and Intestinal Organoids

by Silva, Iris A. L., Railean, Violeta, Duarte, Aires, Amaral, Margarida D.
Published in J Pers Med (2021)

The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hs...

by Farinha, Carlos M, Nogueira, Paulo, Mendes, Filipa, Penque, Deborah, Amaral, Margarida D
Published 2002

Impact of KLF4 on Cell Proliferation and Epithelial Differentiation in the Context of Cystic Fibrosis

by Sousa, Luís, Pankonien, Ines, Simões, Filipa B., Chanson, Marc, Amaral, Margarida D.
Published in Int J Mol Sci (2020)

Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR

by Farinha, Carlos M, Sousa, Marisa, Canato, Sara, Schmidt, André, Uliyakina, Inna, Amaral, Margarida D
Published in Pharmacol Res Perspect (2015)

KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway

by Sousa, Luis, Pankonien, Ines, Clarke, Luka A, Silva, Iris, Kunzelmann, Karl, Amaral, Margarida D
Published in Cells (2020)

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells

by Garcia, Susana M., Casanueva, M. Olivia, Silva, M. Catarina, Amaral, Margarida D., Morimoto, Richard I.
Published 2007

Regulation of the Epithelial Na(+) Channel by the Protein Kinase CK2

by Bachhuber, Tanja, Almaça, Joana, Aldehni, Fadi, Mehta, Anil, Amaral, Margarida D., Schreiber, Rainer, Kunzelmann, Karl
Published 2008

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

by Silva, M. Catarina, Fox, Susan, Beam, Monica, Thakkar, Happy, Amaral, Margarida D., Morimoto, Richard I.
Published 2011

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant

by Matos, Ana M., Pinto, Francisco R., Barros, Patrícia, Amaral, Margarida D., Pepperkok, Rainer, Matos, Paulo
Published in J Biol Chem (2019)

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis

by Pinto, Madalena C, Silva, Iris A L, Figueira, Miriam F, Amaral, Margarida D, Lopes-Pacheco, Miquéias
Published in J Exp Pharmacol (2021)

Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase

by Mendes, Ana Isabel, Matos, Paulo, Moniz, Sónia, Luz, Simão, Amaral, Margarida D., Farinha, Carlos M., Jordan, Peter
Published 2011

LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells

by Luz, Simão, Cihil, Kristine M., Brautigan, David L., Amaral, Margarida D., Farinha, Carlos M., Swiatecka-Urban, Agnieszka
Published 2014

A Mathematical Model of the Phosphoinositide Pathway

by Olivença, Daniel V., Uliyakina, Inna, Fonseca, Luis L., Amaral, Margarida D., Voit, Eberhard O., Pinto, Francisco R.
Published in Sci Rep (2018)

Prolonged co-treatment with HGF sustains epithelial integrity and improves pharmacological rescue of Phe508del-CFTR

by Matos, Ana M., Gomes-Duarte, Andreia, Faria, Márcia, Barros, Patrícia, Jordan, Peter, Amaral, Margarida D., Matos, Paulo
Published in Sci Rep (2018)