Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin

Biosynthesis and folding of multidomain transmembrane proteins is a complex process. Structural fidelity is monitored by endoplasmic reticulum (ER) quality control involving the molecular chaperone calnexin. Retained misfolded proteins undergo ER-associated degradation (ERAD) through the ubiquitin-p...

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Detaylı Bibliyografya
Asıl Yazarlar: Farinha, Carlos M., Amaral, Margarida D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2005
Konular:
Intracellular Trafficking
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140594/
https://ncbi.nlm.nih.gov/pubmed/15923638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.12.5242-5252.2005
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